Ed McIntee, Ph.D.

Associate Professsor of Chemistry 2007Ed McIntee

Ph.D. - University of Minnesota, Twin Cities 1997
B.A. - University of Minnesota, Morris, 1992
Office: Ardolf Science Center  # 247
Phone: (320) 363-5219
Email: [email protected]

Personal Webpage

Courses Taught:

  • CHEM 115: Introduction to Chemistry Topics 1
  • CHEM 116: Introduction to Chemistry Topics 2
  • CHEM 125: Introduction to Chemical Structure and Properties
  • CHEM 201:  Purification and Separation Lab 1
  • CHEM 202:  Purification and Chromatography Lab 2
  • CHEM 250: Reactivity 1
  • CHEM 251: Reactivity 2
  • CHEM 305: Integrated lab
  • CHEM 315: Advanced Reactions (Reactivity 3)
  • CHEM 349: Chemistry in Experience and Practice
  • CHEM 360: Senior Capstone Research
  • CHEM 364: Medicinal Chemistry

Research/Professional Interests:

Phosphatases are enzymes that are involved in the cell signal transduction process.  When information is not properly conveyed in the cell, problems in the generation of signals necessary for different cellular events such as growth, migration, metabolism, gene transcription, cell-cell communication, ion channel activity, immune response and apoptosis/survival decisions occur.  When these events are not controlled, cancer and other disease states such as diabetes occur. Recent studies have assessed the role of LMW PTPs in cell transformation (conversion to cancerous cells).  In theses studies, it was shown that the expression of LWM PTP mRNA and protein is significantly increased in human breast, colon, bladder and kidney tumor samples.  Moreover, its enhanced expression was generally prognostic of a more aggressive cancer.  It has been suggested that LMW PTP may contribute to cancer invasivity (attacking adjacent tissues) by stabilizing cell-cell contacts. Inhibitors of LMW PTP hence may possess potential anti-cancer properties. The goal of my group is to design new inhibitors for LMW-PTP using in silico molecular modeling, synthesize these molecules and test them in a biological assay.  This work is done in collaboration with Dr. Henry Jakubowski.