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Table A: Hazardous Chemicals

Table A-1Select Carcinogens| Table A-2 Chemicals with Extreme Acute or Chronic Health Hazard Ratings| Table A-3 Neurotoxins, Teratogens and Mutagens

Wherever possible in the following tables, the maximum quantity of the substance that can be used in a static atmosphere has been calculated for a typical teaching laboratory of 9000 cubic feet (30x30x10') or 255 cubic meters. These values should only be used as examples.

Parts per million can be converted to milligrams per cubic meter using the following formula:

TLV in mg/m3 =

(TLV in ppm)(gram molecular weight of substance 24.45

Where 24.45 is the molar volume of air in liters at normal temperature and pressure conditions.

Actual quantities allowed should be calculated for the space in which they will be used, if the user suspects that TLV limits might be exceeded.

Table A-1: Select Carcinogens in the CSB/SJU Biology Department

Maximum quantity refers to the maximum quantity that could be spilled and evaporated without exceeding Threshold Limit Values (TLV) in 9000 cubic feet (or 255 cubic meters) typical teaching laboratory lacking air circulation.

Known Human Carcinogens (IARC 1)

CAS # Chemical Molecular Weight TLV Maximum Spill in typical teaching laboratory
71-43-2 Benzene 78.12 0.5 ppm 0.5 milliliters
7778-44-1 Potassium arsenate 180 0.2 mg/m3 51 milligrams
7778-43-0 Sodium arsenate 312 10 ug/m3 2.55 milligrams

Probably Carcinogenic to Humans (IARC 2a)

79-06-1 Acrylamide 71.09 0.03 mg/m3 7.65 milligrams
56-75-7 Chloramphenicol 323.004 none listed
107-06-2 1,2 Dichloroethane

(Ethylene dichloride)

98.96 10 ppm 12.7 milliliters
56-53-1 Diethylstilbestrol 268.4 none given
50-00-0 Formaldehyde 30.03 0.3 ppm 0.09 milliliters (ceiling)
301-04-2 Lead acetate 379.35 50 ug/m3 12.75 milligrams
62-500 Methanesulfonic acid ethyl ether 124.2 none given
66-27-3 Methanesulfonic acid methyl ester 110.1 none given
759-73-9 N-nitroso-N-ethylurea 117.1 none given
684-93-5 N-nitroso-N-methylurea 103.1 none given
95-53-4 Ortho-toluidine 107.16 5 ppm 5.6 grams
124-65-2 Sodium cacodylate (contains arsenic) 214.03 .01 mg/m3 2.55 mg

Possibly carcinogenic to humans (IARC Group 2b)

60-35-5 Acetamide 59.08 15 ppm 9.24 grams
56-23-5 Carbon Tetrachloride 153.84 5 ppm 5.0 milliliters
120-80-9 Catechol 110.11 5 ppm 5.7 grams
67-66-3 Chloroform 119.38 50 ppm 42 milliliters (ceiling)
7791-13-1 Cobalt chloride 237.93 .02 mg/m3 5.1 milligrams
50-29-3 DDT

1,1-Bis(4-chlorophenyl)2,2,2-trichloroethanecjan

~1 mg/m3 255 mg
50-28-2 Beta-estradiol none given
60-11-7 Methyl Yellow 225.29 none given
50-07-7 Mitomycin C none given
Mixture: 52%phenol Phenol/Chloroform/Isoamyl Alcohol 52% Phenol 5 ppm

 

8.8 milliliters
77-09-8 Phenolphthalein 318.33 none listed
57-83-0 Progesterone 314.46 none listed
85-56-9 Propylene oxide 58.08 100 ppm 73 milliliters
141-90-2 Thiouracil 128.15 None listed
62-56-6 Thiourea 76.12 None listed
72-57-1 Trypan Blue 961 None listed
51-79-6 Urethane 89.09 None listed
8008-20-6 Mixture with 5989-27-5 "Wax-Out" (70% Kerosene, 30% D-linonene) Kerosene ~170 Kerosene 100 mg/m3 222 milliliters

References:

2002 TLVs and BEIs, 2002. ACGIH, Cincinnati, OH

IARC Monographs [Jan. 9, 2004] http://monographs.iarc.fr/

Table A-2 Chemicals with Extreme Acute Health Ratings or Extreme Chronic Health Ratings (Level 4) in the CSB/SJU Biology Department

Maximum quantity refers to the maximum quantity that could be spilled and evaporated without exceeding Threshold Limit Values (TLV) in 9000 ft3 typical teaching laboratory lacking air circulation.

CAS # Chemical Molecular Weight TLV Maximum Spill in typical teaching laboratory
66-81-9 Cycloheximide 281.1653 none listed
51-28-5 Dinitrophenol 184.11 None listed
7487-94-7 Mercuric chloride 271.52 0.1 mg/m3 25.5 milligrams
54-11-5 Nicotine 162.2 0.5 mg/ m3 (skin) 0.13 milliliters
151-50-8 Potassium cyanide 65.12 5 mg/m3 1.275 grams (ceiling)
20816-12-0 Osmic Acid 254.2 .002 mg/m3 1 microliter
108-95-2 Phenol 94.11 5 ppm 4.6 milliliters
26628-22-8 Sodium azide 65.02 0.3 mg/m3 74 milligrams
2231-57-4 Thiocarbohydrazide 106.1 None listed

LD50 = 0.02 gm/kg

Table A-3: Embryotoxins, Neurotoxins, Teratogens, and Mutagens in the CSB/SJU Biology Department

Hazard abbreviations are interpreted as follows: EM-Embryotoxin; TE-teratogen; CA-cancer suspect;MU mutagen. Maximum quantity refers to the maximum quantity that could be spilled and evaporated without exceeding Threshold Limit Values (TLV) in 9000 ft3 typical teaching laboratory lacking air circulation.

CAS # Hazard Chemical Molecular Weight TLV Maximum Quantity in typical teaching laboratory
3425-68-21 TE, MU Acetochlor 269.77 None listed
15972-60-8 MU Alachlor 269.77 None listed
50760 EM (TE) Actinomycin D 1255.5 None listed
79-06-1 NE Acrylamide 71.09 0.03 mg/m3 7.65 milligrams
62-53-3 EM Aniline 93.12 5 ppm 4.9 grams
1912-24-9 TE, MU, CA Atrazine 215.68 TWA: 5 mg/m3 1.275 grams
110-26-9 EM, TE Bis-Acrylamide 154.17 None listed
71-43-2 EM, CA Benzene 78.1 0.5 ppm 0.5 milliliters
75-15-0 NE, EM Carbon disulfide 76.1 10 ppm 6.1 milliliters
56-75-7 CA, EM: (MU, TE) Chloramphenicol 323.13 None listed
64868 CA, EM (TE) Colchicine 399.44 None listed
91-64-5 EM Coumarin, anticoagulants 146.14 None listed
21725-46-2 TE Cyanazine 240.69 None listed
66819 EM (TE) Cycloheximide 281.1653 None listed
67-68-5 EM Dimethyl sulfoxide 78.13 None listed
122-39-7 EM Diphenylamine 169.2 10 mg/ m3 2.55 grams
50-29-3 TE, MU, CA DDT ~1 mg/m3 255 milligrams
1239-45-8 EM Ethidium bromide 394.3 None listed
110805 EM (TE) Ethylene glycol monoethyl ether (Cellosolve) 132.2 200 ppm 202 milliliters
64-17-5 EM Ethyl alcohol 46.1 1000 ppm 608 milliliters
50-28-2 EM, CA Estradiol None listed
70-34-8 MU in animals 1-Fluoro-2,4-dinitrobenzene 186.1 None listed
51-21-8 EM: (MU, TE) 5-Fluorouracil 130.08 None listed
76824356 TE in animals Famotidine 337.4 None listed
50-00-0 EM, CA Formaldehyde 30.03 0.3 ppm 0.09 milliliters (ceiling)
75-12-7 EM Formamide 45 10 ppm 4.16milliliters
EM Lead Citrate, dihydrate
103476-89-7 EM (TE) Leupeptin hemisulfate None listed
554-13-2 EM (TE) Lithium carbonate 73.89 None listed
13446-34-9 EM (TE) Manganese chloride 197.91 5 mg/m3 1.275 grams (ceiling)
5121-84-52 TE, MU Metachlor 283.79 None listed
62-50-0 MU, CA Methanesulfonic acid ethyl ester 124.2 none given
66-27-3 EM MU, CA Methanesulfonic acid, methyl ester 110.1 none given
67-56-1 EM (TE) Methyl alcohol 32.04 200 ppm 84 milliliters
593-56-6 possible MU Methoxyamine hydrochloride 83.52
21087-64-9 Metribuzin 214.29 TWA: 5 mg/m3 1.275 grams
54115 EM (TE) Nicotine 162.2 0.5 mg/m3

(skin)

0.13 milliliters
108-95-2 EM Phenol 94.11 5 ppm 4.6 milliliters
7778-43-0 CA, EM: (TE) Sodium arsenate 312 10 ug/m3 2.55 milligrams
3810740 EM (TE) Streptomycin sulfate 1456.84 None listed
60548 EM TE MU Tetracycline 444.44
108-88-3 EM (TE) Toluene 92.056 50 ppm 53 milliliters
51-79-6 CA, EM: (MU TE) Urethane 89.09 None listed
7646-85-7 MU Zinc chloride 136.286 1 mg/m3 TWA 255 milligrams

Reference:

Handbook of Chemical and Environmental Safety in Schools and Colleges. The Forum for Scientific Excellence, Inc. 1990.

Prudent Practices for Handling Hazardous Chemicals in Laboratories. National Academy Press, Washington DC, 1981