Designed by Gregory Freisen of CSNA Architects of Colorado Springs, the New Science Center was constructed in 1997-98 immediately adjacent to and connected to the Peter Engel Science Center. This building houses, for the most part, bench biology: biochemistry, cell biology, microbiology, and histology, along with research space for faculty and students.
Field biology, psychology, astronomy, physics, mathematics, computer science, and geology are taught in the Peter Engel Science Center, and chemistry, nursing, and nutrition are taught at the Ardolf Science Center at The College of Saint Benedict. The New Science Center is also home to the Saint John's Arboretum and to the environmental studies program.
The entry foyer features a Foucault Pendulum under the copper dome, as well a fiber optics depiction of astrological galaxies.